Handling Guide

FLEXcyte iCELL Handling Guide v221012

Service Flyers

innoVitro Cardiac Risk Assays v250703

Electrophysiology, Contractility, Morphology

innoVitro Afib Assay v250723

Modeling Atrial Fibrillation

innoVitro Custom Assays v250813

Customized Assay Solutions for Translational Research

innoVitro Cardiac Characterization Assays v250813

From Ion Channel Activity to Contractile Performance

innoVitro Impedance Assays v250210

Barrier Function, CAR-T, Cell Monitoring, Cytolysis, TEER, GPCR

AppNotes

Evaluating iCell Cardiomyocytes2 in Co-Culture with iCell Cardiac Fibroblasts on the FLEXcyte 96 System

Contractility Analysis of axoCells iPSC-Derived Atrial and Ventricular Cardiomyocytes Assessed on the FLEXcyte 96

Measuring Cardiac Contractility of iCells with the FLEXcyte 96 System

Chronic Cardiotoxic Effects of TKIs and Anthracyclines Analyzed with the FLEXcyte 96

Robustness Study of iCell Lots Performed With FLEXcyte 96

FLEXcyte 96 Pro-Maturation Effect on HiPSC-Derived Cardiomyocytes

FLEXcyte 96 Recordings Compared to Musclemotion Data

Publications

Mechano-Pharmacological Characterization of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells

2016, Cellular Physiology and Biochemistry

Higher Throughput In Vitro Cardiac Contractility Recordings under Physiological Mechanical Conditions

2019, FLEXcyte White Paper

Integration of Mechanical Conditioning Into a High Throughput Contractility Assay for Cardiac Safety Assessment

2020, Journal of Pharmacological and Toxicological Methods

Hybrid Cell Analysis System to Assess Structural and Contractile Changes of HiPSC-CMs for Preclinical Cardiac Risk Evaluation

2022, Journal of Visualized Experiments

Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development

2024, Journal of Pharmacological and Toxicological Methods

Posters

A Higher-Throughput Approach to Investigate Cardiac Contractility In Vitro Under Physiological Mechanical Conditions

2019, Safety Pharmacology Annual Meeting, Barcelona, Spain

Artificial Neural Networks in Cardiac Safety Assessment

2020, Safety Pharmacology Society Annual Meeting, Virtual Event

Mechanical Stimulation in a 2D High-Throughput Contractility System

2021, Society of Toxicology Annual Meeting, Virtual Event

Chronic Cardiotoxic Effects of Kinase Inhibitors and Anthracyclines on Human iPSC-Derived Cardiomyocytes

2021, Society of Toxicology Annual Meeting, Virtual Event

A Physiological Environment for Human iPSC-Derived Cardiomyocytes Facilitates Maturation for Reliable Preclinical Risk Evaluation

2021, EUROoCS Annual Meeting, Virtual Event

Chronic Cardiac Contractility Assessment of Human iPSC-Derived Cardiomyocytes in a Pro-Maturation Environment

2021, 11th World Congress on Alternatives and Animal Use in Life Sciences, Virtual Event

High Throughput Chronic Cardiotoxicity Evaluation of Human iPSC-Derived Cardiomyocytes in a Pro-Maturation Environment

2021, Eurotox Annual Meeting, Virtual Event

Defined Serum-Free Medium and Long-Term Culture on the FLEXcyte 96

2021, Nanion User Meeting, Munich, Germany

How The Environment Alters Gene Expression, Phenotype and Functional Properties of HiPSC-CMs

2021, Safety Pharmacology Society Annual Meeting, Virtual Event

Tackling Chronic Compound Responses of hiPSC-CMs for Preclinical Cardiac Risk Evaluation

2022, Biophysical Society Annual Meeting, SanFransisco, USA

Lot-to-Lot Consistency Study of Commercial Human iPSC- Derived Cardiomyocytes Regarding Contractile Properties

2022, Safety Pharmacology Annual Meeting, Montréal, USA

Assessment of a Smooth Muscle Cell Maturation Protocol for the Analysis of Contractile Properties

2022, Safety Pharmacology Annual Meeting, Montréal, USA

NAM-Related Robustness Analysis of Commercial hiPSC-Cardiomyocytes in the Light of Preclinical Cardiac Risk Assessment

2023, Society of Toxicology Annual Meeting, Nashville, USA

Contractility-Based Pharmacological Characterization of HiPSC-Atrial and Ventricular Cardiomyocytes Assessed on the FLEXcyte 96

2023, Safety Pharmacology Society Annual Meeting, Brussels, Belgium

In Vitro Systems for the Assessment of Chronic Cardiotoxic Effects: News from the HESI Stem Cell Working Group

2024, Society of Toxicology Annual Meeting, Salt Lake City, USA

From Neat Compounds to Complex Mixtures: In Vitro Functional Cardiotoxicity Testing of Botanical Extracts

2025, Society of Toxicology Annual Meeting, Orlando, USA

AF on Demand: A Human iPSC-Derived Screening Assay Targeting Atrial Fibrillation

2025, Society of Toxicology Annual Meeting, Orlando, USA

From Neat Compounds to Complex Mixtures: In Vitro Functional Cardiotoxicity Testing of Botanical Extracts

2025, MPS World Summit, Brussels, Belgium

Modeling Laminopathy-Driven Cardiac Dysfunction Under Microphysiological Conditions: Insights from LMNA L35P Mutant hiPSC-Derived Cardiomyocytes

2025, MPS World Summit, Brussels, Belgium

Videos

FLEXcyte 96 Membranes with Adherent Human iPSC-Derived Cardiomyocytes

FLEXcyte 96 – Investigate In Vitro Cardiac Contractility under Physiological Conditions

FLEXcyte 96 – Contraction Force Analysis

Nanion User Meeting (NUM) 2023

Cardiac Safety Meeting 2023

BSC Annual Meeting 2022

Cardiac Safety Meeting 2021