Morphological Cardiac Liabilities
The Challenge
Cardiac cell morphology and adhesion dynamics are sensitive indicators of sublethal toxicity, but standard assays often overlook these parameters. Morphological deterioration - such as detachment, swelling, or cytoskeletal collapse - can occur before contractile failure and may serve as an early warning signal. However, without real-time structural monitoring, these events go unrecognized, potentially undermining compound de-risking and safety profiling.
Our Solution
To close this gap, we offer impedance-based morphological profiling that can be integrated with or run independently of contractility testing. This approach allows for continuous, label-free tracking of cell shape, adhesion, and monolayer integrity across dosing conditions. The technology has been applied in the CiPA initiative (Comprehensive in vitro Proarrhythmia Assay), reinforcing its value in regulatory-relevant safety screening. By capturing morphodynamic responses alongside function, our platform enhances the sensitivity and resolution of cardiac liability assessment. Whether detecting acute cytotoxicity or subtle chronic stress responses, we provide actionable insights for early safety decision-making.
